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KMID : 0370219960400060679
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Yakhak Hoeji
1996 Volume.40 No. 6 p.679 ~ p.683
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Inhibition of Immediate Allergic Reaction by Eugenol
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김상현/Kim SH
신태용/김형룡/이영미/이은희/신보경/김윤철/안년형/김형민/Shin TY/Kim HY/Lee YM/Lee EH/Shin BK/Kim YC/An NH/Kim HM
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Abstract
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The current study evaluates the capacity of eugenol to regulate immediate allergic reaction by control of histamine release. Administrations of eugenol (1M/kg, i.p.) at 60 min before and 5, 10 min after the compound 48/80 treatment (8mg/kg, i.p.) were shown the mortality rates as 0, 44.4, and 77.8%, respectively. A 60 min before administered group revealed a significant inhibition of serum histamine release compared with those of 5 and 10 min after the compound 48/80 injection. Eugenol (6-48mM) was also showed a dose-dependent activity on the compound 48/80-induced histamine release from the highly purified population of Alcian Blue-positive peritonea] mast cells. These results indicate that in vitro treatment with exogenous eugenol inhibited the active response of mast cell populations and modulated its characteristics.
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